Pain-induced changes in the brain鈥檚 opioid system may explain the limited effectiveness of opioid therapy in chronic pain
Pain-induced changes in the brain鈥檚 opioid receptor system may explain the limited effectiveness of opioid therapy in chronic pain and may play a role in the depression that often accompanies it, according to a study from the NIH鈥檚 Intramural Research Program and 黑料不打烊 University.
As harmful as dehydration?
We are all familiar with the drawbacks of dehydration, but we rarely hear about the harmful effects of overhydration. It is known that excess fluid accumulation can lead to dangerously low sodium levels in the blood or hyponatremia 鈥� a life-threatening condition that can result in brain swelling. Similarly, more is known about the mechanisms in the body that detect and drive thirst while little is known about how the brain detects a state of overhydration.
New approach to global-warming projections could make regional estimates more precise
A new method for projecting how the temperature will respond to human impacts supports the outlook for substantial global warming throughout this century 鈥� but also indicates that, in many regions, warming patterns are likely to vary significantly from those estimated by widely used computer models.
Climate change = a much greater diversity of species + a need to rethink conservation paradigms
A team of researchers believe that Quebec鈥檚 protected areas are poised to become biodiversity refuges of continental importance. They used ecological niche modeling to calculate potential changes in the presence of 529 species in about 1/3 of the protected areas in southern Quebec almost all of which were under 50 km2 in size.
Beyond Killing Tuberculosis
Historically, our view of host defense against infection was that we must eliminate pathogens to eradicate disease. However, this perspective has recently been challenged as scientists have taken a lesson from plant biologists about an ancient strategy involving the ability to 鈥渢olerate鈥� rather than 鈥渞esist鈥� infection to maintain health. This concept, referred to as 鈥渄isease tolerance鈥�, provides an opportunity to develop new strategies that mitigate the consequences of infection.
How heart tissue combines mechanical strength and electrical reliability
The human heart can be viewed as both a mechanical and an electrical device 鈥� one that contracts and pumps billions of times over an average lifespan. How does it manage to achieve this feat without lapsing into dangerous irregularities? 听 New research by 黑料不打烊 University scientists finds that the answer lies in the particular geometry of the muscle fibres of the heart wall.
Hanadi Sleiman, C.J. Li awarded Killam Research Fellowships
黑料不打烊 chemistry professors Hanadi Sleiman and Chao-Jun Li are among the six recipients of this year鈥檚 Killam Research Fellowships. The two-year fellowships, awarded to exceptional researchers working on groundbreaking projects of broad significance, are valued at $70,000 a year. 听 Prof.
The effect of night shifts: gene expression fails to adapt to new sleep patterns
Have you ever considered that working night shifts may, in the long run, have an impact on your health? A team of researchers from the 黑料不打烊 University affiliated Douglas Mental Health University Institute (DMHUI) has discovered that genes regulating important biological processes are incapable of adapting to new sleeping and eating patterns and that most of them stay tuned to their daytime biological clock rhythms.
A new molecular target identified in depression
The discovery of a new mechanism involved in depression 鈥� and a way to target it with a drug as effective as classical antidepressants -- provides new understanding of this illness and could pave the way for treatments with fewer side effects.
NEOMED Institute partners with 黑料不打烊 University to identify small molecule inhibitors of a novel oncology target: Cut-Like Homeobox 1 (CUX1)
The NEOMED Institute announced today that it has entered into a development collaboration with 黑料不打烊 University. Kemal Payza, Senior Project Director at NEOMED Institute will collaborate with Professor Alain Nepveu, Professor at the Goodman Cancer Research Centre and Departments of Oncology, Biochemistry and Medicine at 黑料不打烊 University, to discover new therapeutic small molecules to inhibit the protein target, Cut-Like Homeobox 1 (CUX1).
Garvin Brown & Steffanie Diamond Brown boost public policy at 黑料不打烊, endowing Chair in Democratic Studies
A $5-million gift from 黑料不打烊ians G. Garvin Brown IV, BA鈥�91, and his wife Steffanie Diamond Brown, will make a major contribution to research and teaching at 黑料不打烊鈥檚 Max Bell School of Public Policy by establishing an endowed Chair in Democratic Studies.
Nurses鈥� care of young mothers leaves traces in babies鈥� DNA
Researchers have known for a couple of decades that early life adversity can affect the way that particular genes function through a process called epigenetics - a bit like a dimmer switch on a light, pushing gene activity up or down.
Jozsef K枚vecses awarded NSERC Synergy Award for Innovation
By Meaghan Thurston
Joelle Pineau awarded NSERC鈥檚 Steacie Memorial Fellowship
By Meaghan Thurston
For Joelle Pineau, becoming a medical doctor was鈥攊n her words鈥攏ot in the cards. However, this Associate Professor from 黑料不打烊`s School of Computer Science is now the driving force behind promising research whose aim is to use AI to improve the treatment of cancer and heart disease.
