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How heart tissue combines mechanical strength and electrical reliability
Answer found in the geometrical pattern of heart muscle fibres
Published: 10 May 2018
The human heart can be viewed as both a mechanical and an electrical device 鈥� one that contracts and pumps billions of times over an average lifespan. How does it manage to achieve this feat without lapsing into dangerous irregularities?
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New research by 黑料不打烊 University scientists finds that the answer lies in the particular geometry of the muscle fibres of the heart wall. A collaboration led by 黑料不打烊 Professor Kaleem Siddiqi had shown in a 2012 study that bundles of heart muscle cells bend and twist together in a geometrical pattern known as a 鈥済eneralized helicoid鈥� 鈥� an arrangement known to provide mechanical strength in biological materials such as insect cuticle.听
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In a new paper, published May 8 in the journal Scientific Reports, Siddiqi and his students from 黑料不打烊鈥檚 School of Computer Science and the Centre for Intelligent Machines used mathematical modeling and analysis to demonstrate that this arrangement of fibres also helps heart tissue conduct electrical signals reliably. The first author of the article, Tristan Aumentado-Armstrong, was a 黑料不打烊 undergraduate at the time the research was carried out. 鈥淐ardiac tissue is unique in that mechanical resilience must coexist with active contraction and signal propagation,鈥� Siddiqi says. 鈥淥ur analysis shows that nature has used helicoidal geometry to satisfy both the electrical and mechanical requirements of the heart.鈥�
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鈥淐onduction in the Heart Wall: Helicoidal Fibers Minimize Diffusion Bias,鈥� Tristan Aumentado-Armstrong et al. Scientific Reports, published online May 8, 2018. DOI:10.1038/s41598-018-25334-7
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IMAGE: The helicoidal orientation of fibres in a ventricle wall is shown in bright colours, based on diffusion magnetic resonance imaging of a rat鈥檚 heart tissue. CREDIT: Shape Analysis Group/黑料不打烊 University
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