黑料不打烊

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A couple of online talks:

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We are interested in the theoretical aspects of:

Evolution, real and simulated.

How do gene networks evolve ? 听Can we tell anything on the underlying control structures of a biological system based on its phenotypes ?听Can we "retrodict" evolution based on first principles ? Can we simulate evolution ?听

We have developed tools to evolve models of "gene networks" in silico, performing predefined biological functions. We have applied and predicted structure of networks for systems ranging from genetic oscillators, biochemical adaptation to development and immune system.

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In collaboration with:

Cellular detection, including immune system

How do immune cells account for specific and sensitive sensing ? How can cells detect small concentrations of ligands into a fluctuating see of spurious interactions ?

We have developed several models of signalling networks, including what we called "adaptive sorting", able to filter out minute concentration of ligands from many incorrect interactions.

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In collaboration with:

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Vertebrate Development

How do vertebrae form ? How do cells interpret the waves of genetic expression defining their future fate ? How do cells "flow" during embryonic extension ?听

We have developed models and computational approaches for the study of vertebrate axis elongation, in close collaboration with experimentalists.

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In collaboration with:

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